If you have been reading this book, you probably know that I'm currently writing this blog and I've got a lot of other projects to do in the meantime.
And so I decided to give this a go when I'm not writing about the things that I've discovered while I'm trying to do more writing.
This is my second blog, but I thought I'd share my thoughts on the world of movie making, sex, and movie reviews. I'm really interested in reading all of you who have enjoyed the books I've been reading, and I hope you'll find these thoughts helpful.
And if you're reading this book and you're not sure who's to blame, you may be thinking that there's a whole lot of reasons you're not happy with what I'm doing or that I'm just not a good person to be around.
But I'll try to explain why I'm writing this, why I'm not going anywhere, and what I want to do next.
And then I'll give you a general rundown of what I'm doing, as well as a few things that you may be thinking about, but I hope you'll find these useful.
And here goes:
List of the books I'm reading
1. American Men (1953)
2. I Love Maggie Murdock (1954)
3. The Big Short
4. The American Girl
5. American Men and the Women (1950)
6. The Hard Sell: The Evolution of a Viagra Salesman
7. The Hard Sell: The Evolution of a Maggie Murdock
8.
9. Maggie Murdock (Director, The Last Love Story, etc)
10. Hard Sell: The Last Love Story
11. The Hard Sell: The Last Love Story
12.
13. Maggie Murdock (Director, Love & Kiss, etc)
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
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41. The Last Love Story
42.
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44.
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51.
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Background:Men with idiopathic oligozoospermia (OOS) are often underrepresented in primary care. They often have little or no clinical opportunity to seek care. They are often self-limited on their own, and thus represent an important subgroup in the complex care of these men. The goal of this study was to compare the safety profile of the Sildenafil Citrate in OOS men (Viagra®).
Methods:This was a retrospective analysis of a single national center, including all patients seen by a physician. Inclusion criteria were OOS, age between 18 to 60 years, and male gender. The men were identified and enrolled by the physician in a clinical study. The men were followed up at the physician's clinic for at least six months, at which time they were instructed to take a nitrofurantoin tablet (Viagra®).
Results:Of the 507 men, of whom 207 received the drug, 4 (0.8%) died. Of the remaining 4 (0.8%) men, the median time to death was 4.3 months (IQR: 1.4 to 10.0 months). The median follow-up period was 2.2 months (IQR: 1.4 to 5.0 months) in the 4 men and 1.9 months (IQR: 1.3 to 4.0 months) in the 7 men. The mean baseline Viagra dose was 0.45 mg, with no significant change in the mean dose of Sildenafil. The median time to return of normal sperm motility was 6.1 months in the 4 men and 3.7 months in the 7 men. The median duration of Sildenafil use was 1.6 months (IQR: 0.7 to 1.8 months).
Conclusions:Viagra® was well tolerated, with few men discontinuing the drug. The median time to return of normal sperm motility was 4.1 months and 6.1 months in the 4 men and 3.0 months in the 7 men.
Figure 1: Sperm count, Sildenafil dosage, and time to return of normal sperm motility.Image:Hercali's Syndrome
Figure 2: Sperm histopathology of Sildenafil Citrate-treated men.Key words:Sildenafil, Sildenafil citrate, Male
Figure 3: Sildenafil citrate-treated men.Citation:Hercali M, Poulter D, O'Neil F, Koppel A, et al. Sildenafil Citrate in Men with IPRIS III: Safety and Efficacy Compared with Sildenafil Citrate in the Treatment of Men with OOS. Viagra®. PLoS ONE 12(4): e0252358. https://doi.org/10.1371/journal.pone.0222558
Editor:Bryan C. K. L. Boccard, McGill University, Canada
Received:December 14, 2016;Accepted:February 9, 2017;Published:May 23, 2017
Copyright:©2017erc52. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data:This work is based on a prospective observational cohort study in which the authors were blinded to the results. The authors did not have any relevant data on the Sildenafil Citrate used to treat the men. The authors do not have any relevant data on the Sildenafil Citrate used to treat the men. The men were managed by the same physician who conducted the clinical study, who had an opportunity to evaluate the effect of the drug on sperm motility. The study was approved by the Institutional Review Board of the Canadian Institutes of Health Research (CIRB), the University of Montreal (IRB), and the Canadian Institute for Health Research (CIHR). The Canadian Institutes of Health Research is a provincial research agency under the responsibility of its research unit.
Funding:The study was funded by the Canadian Institutes of Health Research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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